Let's see here, this might be a longer spoiler comment, but I'll try and fit all the changes from the manga in this episode, which is a lot.
The episode adapted chapters 50-56 while skipping chapter 53 all toghether.
Chapter 50 skipped content - Children talking about needing more people to save other kids. They then ask Sonju about other runaway humans and Sonju then explains that there are multiple farms, even those with kids who have no names. And that there are only 4 top tier farms, like Grace Field. And advises them to lure out demons to attack the farms.
The anime only focused on the last part of the chapter, with Sonju and Ray being an anime only scene.
Chapter 51 skipped content - The completely skipped talking about the promise. In the manga when Emma is given the amulet, Mujika tells her about the Seven Walls. And After They leave, Sonju then talks to Mujika and says than only humans can break the promise. Mujika than has an internal monologue, revealing that there is more than one promise. In the end they show Norman and Connie appearing kind of "in spirit" to the kids as a motivation.
The anime then decided to rearrange a lot of scenes from chapter 52 going forward.
Chapters 52-54 - Completely avoided showing "Mister" in the episode, they meet him straight at the point of entering the bunker. Chapter 53 which was skipped, showed his unwelcoming introduction, him denying being Minerva, holding Emma at gunpoint and telling the children to leave. Chapter 54 then focuses more on the conflict, with "Mister" passing out near the end.
The shelter exploration is quite different from the manga as well, I'll try and put it in perspective from the manga here:
Children arrive at the monitor room (52)
Letter from Minerva (56), there's a difference from the manga here: no Goldy Pond coordinates
Conversation in the Kitchen (anime only)
Bathroom (55), Gilda telling them to not use it now (anime only)
Storage room, garden, library (anime only)
Piano (55)
secret room with a passage (anime only), difference from manga: there's an armory there in the manga
Bath and eating (55)
Radio scene (anime only)
Writing on the wall (54), there's a difference from the manga here: says HELP instead of POACHERS
phone call (original)
Now, as to where I think they might be going with it.
I think they might skip Goldy Pond arc altogether, and the "Mister" or Yagoo character as well and they might go in a different direction from here on out.
I hope not, cause unlike many others, I liked the search for minerva and goldy pond arcs quite a bit, they were my favorite. I'd say that after goldy pond, maybe there's room to change stuff, but I'm quite confused as to what they'll do here.